Publikationen

2020

Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T.: Comparative assessment of purified saponins as permeabilization agents during respirometry
Biochim Biophys Acta Bioenerg. 2020 Jun 26;1861(10):148251. pubmed

Bast-Habersbrunner A, Fromme T: Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity.
Front Endocrinol., 2020 Mar 10, 11:118 pubmed

Schöttl T, Pachl F, Giesbertz P, Daniel H, Kuster B, Fromme T, Klingenspor M: Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.Obesity (Silver Spring). 2020 Mar;28(3):590-600. doi: 10.1002/oby.22737. Epub 2020 Feb 7. pubmed

Dieckmann S, Maurer S, Fromme T, Colson C, Virtanen KA, Amri EZ, Klingenspor M: Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue.Front Endocrinol (Lausanne). 2020 Feb 21;11:73. doi: 10.3389/fendo.2020.00073. eCollection 2020. pubmed

Maurer SF, Fromme T, Mocek S, Zimmermann A, Klingenspor M: Uncoupling protein 1 and the capacity for nonshivering thermogenesis are components of the glucose homeostatic system.Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E198-E215. doi: 10.1152/ajpendo.00121.2019. Epub 2019 Nov 12. pubmed

2019

Li Y, Schwalie PC, Bast-Habersbrunner A, Mocek S, Russeil J,Fromme T, Deplancke B, Klingenspor M: Systems genetics-based inference of 1 a core regulatory network underlying white fat browning. Cell-Reports. 2019, Vol. 29:4099–4113. pubmed

Maurer SF, Fromme T, Mocek S, Zimmermann A, Klingenspor M. Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system. Am J Physiol Endocrinol Metab. 2019 Nov 12. pubmed

Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. Sci Rep. 2019 Jun 11;9(1):8470, pubmed

Wang H, Willershäuser M, Karlas A, Gorpas D, Reber J, Ntziachristos V, Maurer S, Fromme T, Li Y, Klingenspor M. A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment. Mol Metab. 2019 Feb; 20:14-27, pubmed

Fromme, Tobias, Hüttinger, Kristina, Maurer, Stefanie, Li, Yongguo, Gantert, Thomas, Fiamoncini, Jarlei, Daniel, Hannelore, Westphal, Sören, Klingenspor, Martin. Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure. In: Scientific Reports (9) 2019, 10.1038/s41598-018-37464-z,  pubmed

 

2018

Schweizer S, Oeckl J, Klingenspor M, Fromme T. Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation.Life Sci Alliance. 2018 Nov 14; 1(6):e201800136, pubmed

Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O'Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M.Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell. 2018 Nov 29; 175(6):1561-157, pubmed

Birnbacher L, Maurer S, Scheidt K, Herzen J, Pfeiffer F, Fromme T. Electron Density of Adipose Tissues Determined by Phase-Contrast Computed Tomography Provides a Measure for Mitochondrial Density and Fat Content. Front Physiol. 2018 Jun 15;9:707, pubmed

U Din M, Saari T, Raiko J, Kudomi N, Maurer SF, Lahesmaa M, Fromme T, Amri EZ, Klingenspor M, Solin O, Nuutila P, Virtanen KA. Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis.Cell Metab. 2018 Jun 6. pii: S1550-4131(18)30327-9, pubmed

Reber J, Willershäuser M, Karlas A, Paul-Yuan K, Diot G, Franz D, Fromme T, Ovsepian SV, Bézière N, Dubikovskaya E, Karampinos DC, Holzapfel C, Hauner H, Klingenspor M, Ntziachristos V. Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients.Cell Metab. 2018 Mar 6;27(3):689-701, pubmed

Fromme T, Kleigrewe K, Dunkel A, Retzler A, Li Y, Maurer S, Fischer N, Diezko R, Kanzleiter T, Hirschberg V, Hofmann T, Klingenspor M. Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity. Mol Metab. 2018 Feb;8:77-85, pubmed

 

2017

Fromme T. Commentary: Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny. Front Physiol. 2017 Nov 28;8:978, Front Physiol

Gerngroß C, Schretter J, Klingenspor M, Schwaiger M, Fromme T. Active brown fat during 18FDG-PET/CT imaging defines a patient group with characteristic traits and an increased probability of brown fat redetection. J Nucl Med. 2017 Jan 19. pii: jnumed.116.183988, pubmed

Tews D, Fromme T, Keuper M, Hofmann SM, Debatin KM, Klingenspor M, Wabitsch M, Fischer-Posovszky P. Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.Mol Cell Endocrinol. 2017 Mar 5;443:106-113, pubmed

Li Y, Fromme T, Klingenspor M. Meaningful respirometric measurements of UCP1-mediated thermogenesis. Biochimie. 2017 Mar;134:56-61, pubmed